Cellular signallingAnimalsSTAT3 Transcription FactorJanus Kinase 1MaleRats
Cornus officinalis total glycosides modulate inflammatory response and inhibit the JAK1/STAT3 pathway within a preclinical rat model of cardiac ischemia/reperfusion-induced injury.
Ke Chen, Yujie Lin, Liudan Chen, Jianjun Li, Aizhen Pan
Published: 202610.1016/j.cellsig.2025.112346
Abstract
OBJECTIVE: Cardiac ischemia/reperfusion (I/R) injury is characterized by excessive inflammation and aberrant activation of intracellular signaling pathways, including JAK/STAT. Cornus officinalis total glycosides (COTG) possess anti-inflammatory prop…
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