Cellular signallingCarcinomaRenal CellHumansUbiquitin ThiolesteraseKidney Neoplasms
Targeting USP28 inhibits clear cell renal cell carcinoma growth.
Ying Ren, Yunfang Yang, Xiaodan Zhu, Lingyi Li, Yaoyao Pan, Hong Sun, Qian Fang, Hui Xiong, Dong Guo, Yongzhan Sun, Hailong Li, Junqi Wang
Published: 202610.1016/j.cellsig.2025.112344
Abstract
Clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, remains challenging to treat due to the lack of effective targeted therapies. Although c-Myc is frequently overexpressed in ccRCC, the mechanisms governing its stability…
Preview only. Read the full abstract at the source