Cellular signallingHumansGATA1 Transcription FactorLeukemiaErythroblasticAcute
Roxadustat induces erythroid differentiation of erythroleukemia cells through the hypoxia inducible factor-α/GATA binding protein 1 axis.
Liqing Yang, Zhehan Luo, Shuang Wang, Jia Lin, Yuanzhong Chen, Yong Wu
Published: 202610.1016/j.cellsig.2025.112340
Abstract
BACKGROUND: Acute erythroleukemia (AEL) is a rare type of acute myeloid leukemia characterized by severe anemia. Roxadustat is a marketed first-generation hypoxia inducible factor-proline hydroxylase inhibitor (HIF-PHI), currently widely used in anem…
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