Cellular signallingHumansPeroxiredoxinsOxidation-ReductionCarcinogenesisNeoplasms
Redox guardian or oncogenic driver? The dual roles of PRDX1 in tumorigenesis.
Li Wang, Yi-di Deng, Jian-Wei Yang, Chang-Yan Li, Lan-Chun Shao, Li Yang, Jin Chai, Shan-Hui Liu, Si-Yu Chen
Published: 202610.1016/j.cellsig.2025.112310
Abstract
Peroxiredoxin 1 (PRDX1) is a thiol-dependent peroxidase with paradoxical roles in cancer. In response to oxidative stress and hyperoxidation of its peroxidatic cysteine, PRDX1 undergoes reversible oligomerization, switching from a peroxidase to a mol…
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