Cellular signallingDoxorubicinAnimalsInterferon-Stimulated Gene Factor 3gamma SubunitCardiotoxicity
Chromatin remodeling factor CHRAC1 regulates doxorubicin-induced cardiotoxicity via IRF9/GSDMD/CASP-1.
Tongtong Zang, Changyi Zhou, Yue Yu, Wenhui Lin, Qiang Xu, Li Shen
Published: 202610.1016/j.cellsig.2025.112290
Abstract
Doxorubicin-induced cardiotoxicity (DIC) is a severe complication of cancer therapy, yet the contribution of epigenetic regulators remains largely unknown. In this study, we identify the chromatin remodeler CHRAC1 as a novel determinant of DIC. Using…
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