Cellular signallingAnimalsMaleLeydig CellsCellular SenescenceMice
Deficiency of NR2C2 accelerates senescence of testicular Leydig cells and infertility in male mice.
Dalian Gong, Zhihui Liu, Rongda Kang, Xiaowen Liu, Ziqian Min, Huan Xin, Yanan Liu, Yuanyuan Chen, Min Liu, Ying Liang, Anji Chen, Lifang Yang, Zenghui Mao, Dan Li
Published: 202610.1016/j.cellsig.2025.112284
Abstract
The Leydig cell is one of the components that make up the testicular microenvironment, playing a crucial role in male reproductive function by secreting androgens and cytokines. The present study found that knocking down NR2C2, a member of the 2C gro…
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