Cellular signallingAnimalsMicroRNAsExosomesTOR Serine-Threonine KinasesPTEN Phosphohydrolase
hPMSC-derived Exosomal miR-26-5p modulates macrophage polarization for liver repair in DILI via PTEN/mTOR signaling.
Zhi Zhang, Yu Fu, Shuyi Wei, Liwei Liang, Ting Li, Lei Feng, Lei Cai, Shunjun Fu, Yang Li, Shao Li, Mingxin Pan, Guolin He
Published: 202610.1016/j.cellsig.2025.112272
Abstract
BACKGROUND: The paracrine mechanisms of Mesenchymal Stem Cells (MSCs) involve the release of bioactive components, including exosomes. Although the crucial role of macrophage polarization in acute liver injury has been established by previous studies…
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