Cellular signallingCarcinomaHepatocellularReceptorsCCR3Liver Neoplasms
Hepatic stellate cells shape the ECM-disorganized and immunosuppressive microenvironment via CCL11/CCR3 axis in lenvatinib-treated hepatocellular carcinoma.
Na Qiang, Cheng Lan, An Lin, Hiroaki Kanzaki, Masanori Inoue, Naoya Kanogawa, Takayuki Kondo, Sadahisa Ogasawara, Masato Nakamura, Shingo Nakamoto, Dawei Cui, Hang Lv, Qiuran Xu, Guiping Chen, Junjie Ao
Published: 202610.1016/j.cellsig.2025.112263
Abstract
Hepatic stellate cell (HSC) activation plays a crucial role in the progression from chronic liver disease to hepatocellular carcinoma (HCC) by establishing disorganized extracellular matrix (ECM) and facilitating immune evasion. However, the effects…
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