Cellular signallingNaphthoquinonesPolo-Like Kinase 1HumansApoptosisProto-Oncogene Proteins
PLK1 inhibition by Shikonin attenuates oral cancer growth through β-catenin-mediated regulation of EMT and apoptosis.
Stuti Biswal, Sruti Biswal, Bibekanand Mallick, Bijesh K Biswal
Published: 202610.1016/j.cellsig.2025.112262
Abstract
Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy characterized by poor prognosis, frequent recurrence, and limited effective therapeutic options. Shikonin (Shk), a bioactive naphthoquinone derivative isolated from the roots of Li…
Preview only. Read the full abstract at the source