Cellular signallingAnimalsPyroptosisToll-Like Receptor 2NLR FamilyPyrin Domain-Containing 3 Protein
TLR2 signalling triggers NLRP3 inflammasome-mediated microglial pyroptosis promotes neonatal hypoxic-ischemic brain injury.
Fei Ruan, Wei Bao, Jing Hu, Haicheng Wen, Di Wu, Jiasui Yu, Zhiping Song, Qi Xiong, Kai Le
Published: 202610.1016/j.cellsig.2025.112251
Abstract
Neonatal hypoxic-ischemic encephalopathy (HIE) causes severe neurological damage. The extensive cell death and subsequent inflammation observed in the brain following hypoxic-ischemic (HI) injury suggest that pyroptosis, an inflammation-associated fo…
Preview only. Read the full abstract at the source