Cellular signallingHumansGastrointestinal MicrobiomeHomeostasisExtracellular MatrixAnimals
The gut microbiota-derived metabolites regulate bone extracellular matrix homeostasis: Mechanisms and therapeutic implications.
Yuanliang Li, Kai Liu, Yugu Li, Zhaoxin Tang, Ying Li, Aoyun Li, Hui Zhang
Published: 202610.1016/j.cellsig.2025.112245
Abstract
The bone extracellular matrix (ECM) is a dynamic scaffold crucial for skeletal integrity, and its dysregulation underpins pathologies such as achondroplasia (ACH), osteoporosis (OP), and osteoarthritis (OA). Emerging evidence reveals that the gut mic…
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