Cellular signallingCarcinomaRenal CellHumansKidney NeoplasmsUbiquitination
DTX3L promotes renal cell carcinoma progression via ubiquitination and degradation of LATS2.
Yeqing Yuan, Bin Lyu, Zhimin Chu, Mingqing Wu, Yixiang Zhang
Published: 202610.1016/j.cellsig.2025.112216
Abstract
Renal cell carcinoma (RCC) remains a therapeutic challenge due to incomplete understanding of its molecular drivers. This study identifies DTX3L as a novel oncogenic E3 ubiquitin ligase in RCC through comprehensive multi-omics analysis. We demonstrat…
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