Cellular signallingIodatesNecroptosisAnimalsRetinal Pigment EpitheliumHumans
PYGM downregulates necroptosis signaling to attenuate sodium iodate-induced RPE cell degeneration.
Yaqi Cheng, Simin Gu, Huan Yu, Jiayi Jin, Huanhuan Cheng, Huini Zhang, Jiayi Lin, Meng Li, Haocheng Zhu, Tao Wang, Qunai Huang, Yingjie Liu, Pengjie Yue, Weihua Li, Shiqi Ling
Published: 202610.1016/j.cellsig.2025.112206
Abstract
BACKGROUND: Age-related macular degeneration (AMD) causes incurable vision loss in elderly individuals, and there is currently only a rarely effective treatment for dry AMD. Necroptosis is attracting increasing attention in the context of AMD. This s…
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