Cellular signallingAnimalsVitamin D DeficiencyPulmonary FibrosisMicePolycomb Repressive Complex 1
Bmi-1 overexpression mitigates vitamin D deficiency-induced pulmonary fibrosis via TIME pathway.
Jin'ge Zhang, Mingxin Huang, Jiawen Zhou, Haiyun Chen, Ziyang Wang, Jianliang Jin, Lei Shu, Dengshun Miao
Published: 202510.1016/j.cellsig.2025.112180
Abstract
Vitamin D deficiency is increasingly linked to senescence-associated pulmonary fibrosis (SAPF), yet the underlying mechanisms remain incompletely understood. Here, we demonstrate that mesenchymal cell-specific overexpression of Bmi-1 significantly am…
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