Cellular signallingHumansTriple Negative Breast NeoplasmsHypoxia-Inducible Factor 1alpha SubunitNephroblastoma Overexpressed Protein
CCN3/IMP3/HIF1α positive feedback loop enhances malignant progression of triple-negative breast cancer.
Seogho Son, Seohee Jo, Hogeun Lim, Min-Gyeong Kang, Joo-Hyung Lee, Chang-Jun Lee, Kyung-Min Lee, Incheol Shin
Published: 202510.1016/j.cellsig.2025.112179
Abstract
Cancer cells are often exposed to a hypoxic environment due to indiscriminate proliferation and incomplete vasculature formation. Hypoxia-inducible factor-1 (HIF-1), which is induced by a hypoxic environment, promotes tumor malignancy by regulating c…
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