Cellular signallingrho-Associated KinasesHumansColorectal NeoplasmsLiver NeoplasmsAnimals
ROCK1 drives colorectal cancer liver metastasis via PRKCH-mediated bioenergetic reprogramming.
Yue Luo, Yishan Xu, Xi Chen, Shitong Wang, Xinheng Liu, Guihua Jin, RenPin Chen, Huajun Yu, Liyi Li
Published: 202610.1016/j.cellsig.2025.112174
Abstract
Colorectal cancer (CRC) metastasis, particularly to the liver, is a primary contributor to cancer-related deaths, yet the underlying molecular drivers remain insufficiently defined. This study identifies Rho-associated coiled-coil kinase 1 (ROCK1) as…
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