Cellular signallingAnimalsNF-E2-Related Factor 2AutophagyKelch-Like ECH-Associated Protein 1Oxidative Stress
The role and mechanism of autophagy-regulated Keap1/Nrf2 pathway in oxidative stress-induced cartilage endplate cell apoptosis.
WenJing Wang, Kui Deng, WenZhao Chen, LiuXue Du, JiangWei Chen
Published: 202510.1016/j.cellsig.2025.112153
Abstract
BACKGROUND: Intervertebral disc degeneration (IVDD), a leading cause of chronic low back pain, involves oxidative stress, impaired autophagy, and apoptosis. However, the dynamic crosstalk among Kelch-like ECH-associated protein 1/Nuclear factor eryth…
Preview only. Read the full abstract at the source