CellAnimalsMultiple SclerosisMiceCD4-Positive T-LymphocytesHumans
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis.
Olivia G Thomas, Urszula Rykaczewska, Marina Galešić, Rianne T M van der Burgt, Nils Hallén, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Riqué, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, András Levente Szonder, Chiara Sorini
Published: 202610.1016/j.cell.2025.12.032
Abstract
Epstein-Barr virus (EBV) infection constitutes a prerequisite for multiple sclerosis (MS) development, and cross-reactivity between EBV nuclear antigen 1 (EBNA1) and anoctamin-2 (ANO2) antibodies was previously demonstrated in persons with MS (pwMS).…
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