Cell
A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator.
Guodong He, Qinxin Sun, Xinyu Xu, Fang Kong, Shuhao Zhang, Kexin Ye, Xiaoou Sun, Bin Lin, Xin Chen, Chuangye Yan, Xiangyu Liu
Published: 202610.1016/j.cell.2025.12.023
Abstract
Approximately one-third of clinical drugs mediate their therapeutic effects through G protein-coupled receptors (GPCRs), highlighting their immense therapeutic relevance. Novel approaches to modulate GPCR activity have the potential to yield unique p…
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