Cell
MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids.
Leonie Uhl, Amel Aziba, Sinah Löbbert, Timothy Russell, Bastian Krenz, Francisco Montesinos, Toshitha Kannan, Omkar R Valanju, Christina Schülein-Völk, Tim de Martines, Michael Bolz, Daniel Fleischhauer, Giacomo Cossa, Theresa Endres, Daniel Solvie
Published: 202610.1016/j.cell.2025.12.019
Abstract
In response to perturbed transcription elongation, the MYC oncoprotein multimerizes and undergoes a phase transition. Here, we demonstrate that MYC globally relocalizes from its canonical positions on DNA to nascent RNA upon accumulation of intronic…
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