Cell
FOCAS: Transcriptome-wide screening of individual m6A sites functionally dissects epitranscriptomic control of gene expression in cancer.
Xinning Zhang, Yifan Zhang, Xinyu Liu, Chang Liu, Ying Liu, Yuan He, Yuhang Qiu, Lida Sun, Jing Hu, Yawei Gao, Wensheng Wei, Jun Liu
Published: 202510.1016/j.cell.2025.11.037
Abstract
Although N6-methyladenosine (m6A) is a pervasive RNA modification essential for gene regulation, dissecting the functions of individual m6A sites remains technically challenging. To overcome this, we developed functional m6A sites detection by CRISPR…
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