Cell
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases.
Min Kyung Shinn, Dylan T Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, You Jin Song, Yuna Ayala, Kiersten M Ruff, Gregory W Strout, Matthew D Lew, Kannanganattu V Prasanth, Rohit V Pappu
Published: 202510.1016/j.cell.2025.11.026
Abstract
Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific sequence grammars. Such proteins include serine/arginine-rich splicing factors (SRSFs) and transactive…
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