CellFerroptosisPhospholipid Hydroperoxide Glutathione PeroxidaseAnimalsHumansMice
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.
Svenja M Lorenz, Adam Wahida, Mark J Bostock, Tobias Seibt, André Santos Dias Mourão, Anastasia Levkina, Dietrich Trümbach, Mohamed Soudy, David Emler, Nicola Rothammer, Marcel S Woo, Jana K Sonner, Mariia Novikova, Bernhard Henkelmann, Maceler Aldrovandi
Published: 202610.1016/j.cell.2025.11.014
Abstract
Ferroptosis, driven by uncontrolled peroxidation of membrane phospholipids, is distinct from other cell death modalities because it lacks an initiating signal and is surveilled by endogenous antioxidant defenses. Glutathione peroxidase 4 (GPX4) is th…
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