CellHumansChromatinThermodynamicsKruppel-Like Transcription FactorsTranscription Factors
Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells.
Julia M Schaepe, Torbjörn Fries, Benjamin R Doughty, Vivekanandan Ramalingam, Betty B Liu, Olivia J Crocker, Georgi K Marinov, Michaela M Hinks, Emil Marklund, William J Greenleaf
Published: 202610.1016/j.cell.2025.11.008
Abstract
The molecular details governing transcription factor (TF) binding and the formation of accessible chromatin are not yet quantitatively understood-including how sequence context modulates affinity, how TFs search DNA, the kinetics of TF occupancy, and…
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