CellAlzheimer DiseaseAnimalsHumansMiceReceptor
Elucidating pathway-selective biased CCKBR agonism for Alzheimer's disease treatment.
Jia-Le Wang, Xue-Ying Sha, Yue Shao, Zi-Hao Zhang, Shen-Ming Huang, Hui Lin, Shi-Yi Gan, Nan Zhang, Xin-Yi Xia, Yu-Nan Sun, Jin-Hui Ding, Rui-Qi Zhao, Jie Cheng, Pan Shang, Jin-Peng Wang
Published: 202610.1016/j.cell.2025.10.034
Abstract
Expressed in the entorhinal cortex (EC), the cholecystokinin (CCK) B receptor (CCKBR) plays an important role in memory and learning. Here, we identify that CCKBR-Gs and -Gq signaling, rather than CCKBR-Gi signaling, are beneficial for Alzheimer's di…
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