Cell calcium
Isoform-specific structure and function of calsequestrin: Implications beyond calcium buffering in health and disease.
Punyadhara Pani, Diya Aich, Barsha Priyadarshini Kar, M Shiwangi Giri, Gourabamani Swalsingh, Muthu Periasamy, Naresh Chandra Bal
Published: 202610.1016/j.ceca.2026.103120
Abstract
Calsequestrin (CASQ) plays an important role in muscle contraction by buffering Ca2+ inside the sarcoplasmic reticulum (SR). Intriguingly, mammals express two CASQ isoforms encoded by separate genes with highly conserved protein structure. CASQ1 is m…
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