Cell calciumAnimalsMyocytesCardiacCalmodulinProtein Biosynthesis
Nuclear Ca2+-Calmodulin signaling in cardiac myocytes reduces catecholamine-evoked protein translation and prevents hypertrophy.
Anja Riedel, Rebekka Medert, Sara Monaco, Enio Gjerga, Xenia Tolksdorf, Christin Richter, Michelle Malz, Meike Schrader, Vladimir Kuryshev, Martin Busch, Andreas Jungmann, Zoe Löwenthal, Koenraad Philippaert, Angela Wirth, Roger Ottenheijm
Published: 202610.1016/j.ceca.2025.103101
Abstract
Cardiac remodeling, including hypertrophy, is associated with alterations in cytosolic Ca2+ homeostasis of cardiac myocytes that spill over into the nucleoplasm. To test whether nuclear Ca2+ signaling acts causally on the development of cardiac hyper…
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