Contemporary clinical trialsHumansStress DisordersPost-TraumaticDronabinolDouble-Blind Method
Randomized trial of delta-9-tetrahydrocannabinol (THC) versus placebo to augment the effects of prolonged exposure therapy on fear extinction learning in post-traumatic stress disorder: Study rationale and protocol.
Christine A Rabinak, Paul E Kilgore, Mark A Lumley, Sheila A M Rauch
Published: 202610.1016/j.cct.2025.108148
Abstract
BACKGROUND: Prolonged exposure (PE) therapy is effective for PTSD, yet dropout and partial response remain concerning. Preclinical and human studies suggest Δ9-tetrahydrocannabinol (THC) enhances fear extinction and recall through brain cannabinoid r…
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