Contemporary clinical trialsHumansResearch DesignAdolescentCritical IllnessRandomized Controlled Trials as Topic
Enhanced trial efficiency of the novel "contemporaneous control recapture" parallel-cohort RCT design: Methods and application in the CRITICAL-Kids-TP trial.
Anthony A Sochet, Ernest K Amankwah, Vahid Andalib, Julie Jaffray, Christoph Male, E Vincent Faustino, Neil A Goldenberg, Pedi-ATLAS Group and the Antithrombotic Trials Working Party of the Pediatric Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
Published: 202610.1016/j.cct.2025.108142
Abstract
The efficiency and generalizability of the traditional randomized clinical trial (RCT) design are reduced by the exclusion of otherwise eligible participants who decline randomization or undergo early withdrawal due to missed protocol-specified windo…
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