Cancer cellFemaleHumansMaleMiddle AgedAntigens
Antigen-specific profiling identifies T-bet+ melanoma-specific CD8+ T cells associated with response to neoadjuvant PD-1 blockade.
Guanning Wang, Daniel Yoon, Ajeya Nandi, Khushboo Patel, Tarek Azar, Justin Kim, Nicholas A Han, Aaron Nickie, Stella Park, Kevin Wang, Patrick Yan, Shraya Divaker, Jennifer Tabita-Martinez, Lydia Giles, Mary Carberry
Published: 202610.1016/j.ccell.2025.12.004
Abstract
Despite widespread immune profiling in cancer immunotherapy, the antigen-specific responses that drive clinical outcomes remain poorly defined. In a prospective neoadjuvant trial (NCT04013854) of a single-dose anti-PD-1 (nivolumab) in stage III melan…
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