Cancer cellHumansNeoplasmsMediator Complex Subunit 1Enhancer ElementsGenetic
MED1-driven ecDNA super-enhancers in cancer.
Jiaqi Zhou, Xing Kang, Yang Zhang, Haiyun Gan
Published: 202510.1016/j.ccell.2025.10.011
Abstract
Extrachromosomal circular DNA (ecDNA), enriched with enhancers, drives oncogenic transcription and tumor progression, but the mechanisms remain elusive. In this issue of Cancer Cell, Wei et al. uncover MED1-driven ecDNA super-enhancers as regulatory…
Preview only. Read the full abstract at the source