Chemico-biological interactions
Environmental pyridinium disinfectants impair cortisol metabolism via 11β-hydroxysteroid dehydrogenase 2 inhibition: A cross-species risk evaluation.
Chaochao Gong, Xiuzhi Zhang, Yu Zhang, Xishi Chen, Hao Lin, Ren-Shan Ge, Youming Zhao
Published: 202610.1016/j.cbi.2026.111914
Abstract
11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2), a key enzyme in glucocorticoid inactivation, is expressed in human and rat placentas and kidneys. However, the inhibitory effects of alkyl (C1-C20) pyridinium quaternary ammonium disinfectants (PYRs…
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