Chemico-biological interactionsHumansStructure-Activity RelationshipChalconesApoptosisAntineoplastic Agents
Structure-activity relationships reveal a 4-(2-pyridyl)chalcone as a potent cell death inducer.
Juan Perdomo, Henoc Del Rosario, Ester Saavedra, Mercedes Said, Celina García, Lía Cruces, Susana Abdala, Ignacio Brouard, José Quintana, Francisco Estévez
Published: 202610.1016/j.cbi.2025.111877
Abstract
Chalcones are biosynthetic precursors of flavonoids and are considered potential anticancer drugs. Here, twenty-two chalcones were synthesized and evaluated for their effects on the viability of eight human leukaemia cells. This series of chalcones w…
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