Chemico-biological interactionsAnimalsOxidative StressApoptosisMaleRats
Unsymmetrical dimethylhydrazine induces dose-dependent liver toxicity in rats via oxidative stress and PI3K/Akt pathway-mediated apoptosis.
Jiawei Zheng, Luting Wu, Xueming Duan, Wei Ding, Jiayou Zhou, Shuai Zhou, Donghui Wu, Hongguo Li
Published: 202610.1016/j.cbi.2025.111852
Abstract
Unsymmetrical dimethylhydrazine (UDMH), a hypergolic propellant widely used in aerospace, is classified as a Group 2B carcinogen. Although UDMH induces dose-dependent hepatotoxicity, the underlying mechanisms remain unclear. This study tested the hyp…
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