Chemico-biological interactionsHumansGlutamineFluorouracilCarcinomaHepatocellular
GLS1 inhibitor CB-839 inhibits the malignant progression of 5-FU resistant hepatoma cells by regulating glutamine metabolism.
Hao Wang, Xiao-Yan Wang, Jian-Bo Ji, Zong-Xue Zheng, Peng-Fei Shang, Xiu-Li Guo
Published: 202610.1016/j.cbi.2025.111812
Abstract
Liver cancer, primary hepatocellular carcinoma (HCC), posing a significant threat to human health due to its high prevalence and limited treatment options. As a first-line chemotherapeutic agent for HCC, 5-fluorouracil (5-FU) has demonstrated signifi…
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