Chemico-biological interactionsReceptorsAryl HydrocarbonNeuroblastomaHumansAnimals
Targeting neuroblastoma with 3β,5α-tetrahydrocorticosterone: Activation of aryl hydrocarbon receptor inhibits tumor growth, metastasis, and stemness while promoting neural differentiation.
Zhu-Qian Wen, Wen-Ming Hsu, Chien-Chun Chiou, Farhan Azhwin Maulana, Chia-Hwa Chang, Jie-Ming Huang, Zhi-Kai Yu, Chien-Chin Chen, Neng-Yu Lin, Chun-Fa Tsai, Jheng-Siou Lai, Yue-Ling Chen, Pei-Yi Wu
Published: 202510.1016/j.cbi.2025.111780
Abstract
Neuroblastoma (NB) is a highly malignant pediatric cancer that originates from the sympathoadrenal lineage of the neural crest. Recent studies have suggested the aryl hydrocarbon receptor (AHR) pathway as a promising therapeutic target for NB. In thi…
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