Carbohydrate researchSubstrate SpecificityRibosePurinesPyrimidine PhosphorylasesMolecular Docking Simulation
Impact of 6-purine modifications on the ribose substrate selectivity of pyrimidine nucleoside phosphorylase (PyNP) in base exchange reactions.
Akihiko Hatano, Riki Matsuzaka, Rai Hamano, Genki Shimane, Toranosuke Fukatsu, Hibiki Okumoto, Masatoshi Kidowaki, Toshifumi Konishi
Published: 202610.1016/j.carres.2025.109739
Abstract
Pyrimidine nucleoside phosphorylase (PyNP) catalyzes phosphorolysis and base exchange reactions, providing an eco-friendly and stereoselective approach for synthesizing unnatural nucleosides. This study investigates PyNP substrate specificity, partic…
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