Cancer lettersHumansColorectal NeoplasmsUbiquitin ThiolesteraseCell ProliferationUbiquitin-Protein Ligases
A TRIM21-UCHL3-ITCH-SIPA1 axis promotes colorectal cancer growth and metastasis.
Shenghan Lou, Hao Wang, Genshen Mo, Hao Li, Haonan Xie, Yuze Huang, Huiying Li, Keru Ma, Xinyue Zhang, Meihong Yan, Jian Zhang, Yanan Pi, Peng Han
Published: 202610.1016/j.canlet.2025.218221
Abstract
Dysregulation of protein ubiquitination and deubiquitination is a key mechanism driving tumor progression. However, the role of upstream regulators and post-translational mechanisms regulating signal-induced proliferation-associated 1 (SIPA1) stabili…
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