Cancer lettersHumansSirtuin 1Femalebeta CateninNeoplastic Stem Cells
Cytoplasmic SIRT1 enhances the stemness of polyploid giant cancer cells by promoting β-catenin protein stability and nuclear accumulation in ovarian carcinoma upon neoadjuvant chemotherapy.
Hong Xu, Shujun Zeng, Minmin Wang, Yinmei Wang, Yixin Cao, Yuling Qu, XinYi Huang, Xia Li, Qing Qiao, Jing Zhang
Published: 202610.1016/j.canlet.2025.218193
Abstract
Epithelial ovarian carcinoma, the deadliest gynecological malignancy, frequently develops treatment resistance through polyploid giant cancer cells (PGCCs) that typically emerge after carboplatin-paclitaxel chemotherapy. Accumulating evidence suggest…
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