Cancer lettersHumansB7-H1 AntigenMembrane ProteinsTumor EscapeCell Line
TMEM199 promotes PD-L1 expression and tumor immune evasion by activating the recycling of IFNGR1/2.
Ting Li, Miner Xie, Ruhua Zhang, Jianliang Zhong, Zhenxuan Chen, Jiahui Lin, Yezi Zou, Yuanzhong Wu, Tiebang Kang, Liwen Zhou
Published: 202610.1016/j.canlet.2025.218187
Abstract
Immune checkpoint blockade (ICB) therapies targeting the programmed cell death 1 (PD-1)/PD-1 ligand 1 (PD-L1) axis provide significant clinical benefits across multiple tumor types. Although interferon (IFN)-γ is essential for anti-tumor immunity, su…
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