Cancer lettersTriple Negative Breast NeoplasmsHumansFemaleAnimalsChemokine CCL2
BMP9 potentiates immunotherapy in triple-negative breast cancer by suppressing Tregs infiltration via the PRKDC-CCL2 axis.
Yiqing You, Lan Wei, Meng Dai, Guozhi Zhao, Kun Fan, Tingting Dang, Haoli Sun, Liang Zhang, Qian Li, Mengxin Sun, Xiaolu Li, Xiran He, Shiyu Yang, Tao Zeng, Jiafeng Tang
Published: 202610.1016/j.canlet.2025.218175
Abstract
Immunotherapy represents a pivotal strategy for triple-negative breast cancer (TNBC), yet its efficacy is constrained by the immunosuppressive tumor microenvironment (TME). In this study, we demonstrate that bone morphogenetic protein-9 (BMP9) inhibi…
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