Cancer lettersNucleotidyltransferasesManganeseAnimalsHumansMice
Manganese mediates nucleoplasm distribution of cGAS to enhance systemic antitumor immunity and drive abscopal effect.
Tiance Wang, Zijian Lv, Runjia Fan, Jiejie Liu, Yan Zhang, Chunmeng Wang, Qianyi Ming, Meixia Chen, Yulin Jia, Qingming Yang, Zhengfan Jiang, Qian Mei, Weidong Han
Published: 202610.1016/j.canlet.2025.218154
Abstract
Abscopal effect remains rare and clinically unpredictable because of immunosuppressive mechanisms and inadequate immune activation. This phenomenon may stem from cyclic GMP-AMP synthase (cGAS) sequestration within the nucleus, where high-affinity nuc…
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