Cancer lettersHumansTumor MicroenvironmentNeoplasm MetastasisNeoplasmsBiomechanical Phenomena
Biomechanical networks of the pre-metastatic niche: Decoding biophysical determinants of tumor metastatic organotropism.
Zichen Guo, Jingyang Liu, Minpu Zhang, Wenfu Zheng, Jing Zhuang, Changgang Sun
Published: 202510.1016/j.canlet.2025.218102
Abstract
In the metastatic cascade, biomechanics acts as an invisible engine that drives tumor malignancy. Shaping the intrinsic mechanical microenvironment of cancer cells facilitates their distant colonization and metastasis. Mechanical cues serve as physic…
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