Cancer lettersTemozolomideGlioblastomaHumansDrug ResistanceNeoplasm
Targeting the FBXO5-DOK6 axis to overcome temozolomide resistance in glioblastoma via proteasome-cytomechanics regulation.
Chao Wang, Mengqi Wang, Zhenye Zhu, Huang Tan, Danchen Su, Mu Qiao, Mingru Jiang, Fengyuan Che
Published: 202510.1016/j.canlet.2025.218072
Abstract
The development of resistance to temozolomide (TMZ) represents a critical challenge in the management of glioblastoma (GBM), yet the molecular basis for this resistance is still not fully elucidated. In this study, we utilized a custom-designed CRISP…
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