Cancer genetics
In silico identification of deleterious NT5C2 and PRPS1 mutations driving thiopurine resistance in relapsed acute lymphoblastic leukemia.
Ramita Sharma, Jeeshitha Kudithipudi, Himanshu Singh, Dhamodharan Prabhu, Sugunakar Vuree
Published: 202610.1016/j.cancergen.2026.01.001
Abstract
Relapse in Acute Lymphoblastic Leukemia (ALL) are often driven by multiple factors, including thiopurine drug-resistant mutations in NT5C2 and PRPS1. To determine the functional significance of these mutations, we employed comprehensive computational…
Preview only. Read the full abstract at the source