Cancer geneticsHumansGerm-Line MutationPolymorphismSingle NucleotideLung Neoplasms
Germline lung cancer SNPs dysregulate known (LATS1) and novel (ADCY2) oncogenes through distal, spatially-constrained eQTLs.
Aldric Khoo, Michael Pudjihartono, Justin M O'Sullivan, William Schierding
Published: 202610.1016/j.cancergen.2025.11.004
Abstract
Understanding how genomic variants contribute to lung cancer (LC) risk is key to better understanding the molecular mechanisms underlying that risk. While genome-wide association studies (GWAS) have identified numerous LC risk loci, most single nucle…
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