Brain research bulletin
HSP47 inhibitor Col003 inhibits glial scar formation and improves neurological function in ischemic stroke in rats.
Kejian Zhou, Yuliang Xie, Xiaoyun Xie, Haoying Li, Tingting Liang, Jinpin Li, Jingli Liu
Published: 202610.1016/j.brainresbull.2026.111745
Abstract
BACKGROUND: Glial scarring is a major obstacle for axonal regeneration and neural repair in the late stage of ischemic stroke. Reactive astrocytes are the main component of the glial scar. Heat shock protein 47 (HSP47) is significantly expressed in r…
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