Brain research bulletinAnimalsAmyloid beta-PeptidesMemory DisordersPeptide FragmentsMice
Exogenous Aβ1-42 monomers rescue memory deficits in presenilin-1 and presenilin-2 conditional double knockout mice.
Jinnan Chen, Bo Wang, Zhidong Chen, Fan Ding, Jiayue Wang, Chaoyang Ding, Xiaohua Cao
Published: 202610.1016/j.brainresbull.2026.111715
Abstract
Emerging evidence challenges the direct causal relationship between amyloid-β (Aβ) deposition and cognitive decline in Alzheimer's disease (AD), as exemplified in presenilin-1 and presenilin-2 conditional double knockout (cDKO) mice which exhibit no…
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