Brain research bulletinAnimalsGastrointestinal MicrobiomeVagus NerveMiceMale
A vagus-dependent gut microbiota-metabolite axis drives chronic inflammatory pain and working-memory deficits in mice.
Cai-Bao Yue, Wei-Wei Luan, Di Qiu, Xin Ding, Han-Wen Gu, Pan-Miao Liu, Kenji Hashimoto, Jian-Jun Yang, Xing-Ming Wang
Published: 202610.1016/j.brainresbull.2025.111702
Abstract
Chronic inflammatory pain (CIP) has been increasingly linked to gut microbiota (GM)-brain interactions, yet whether these effects rely on vagal signaling remains unclear. Here, we investigated whether GM from CIP mice is sufficient to transfer pain-l…
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