Brain research bulletin
Inhibition of SCD1 attenuates neuroinflammation and brain injury after cerebral ischemia-reperfusion.
Shuangkai Li, Xiang Li, Lu Peng, Haojie Ding, Xuan Shi, Jiale Liu, Haiying Li, Jianguo Xu, Qing Sun
Published: 202510.1016/j.brainresbull.2025.111693
Abstract
Neuroinflammation mediated by microglial hyperactivation represents a pivotal pathological mechanism exacerbating neuronal damage following cerebral ischemia. Stearoyl-CoA desaturase 1 (SCD1), the rate-limiting enzyme in monounsaturated fatty acid sy…
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